Anti-Doublestranded Dna Antibodies
About two-thirds of patients with active systemic lupus erythematosus (SLE) have measurable levels of autoantibodies to doublestranded (native) deoxyribonucleic acid (known as anti-ds-DNA). These antibodies are rarely detected in patients with other connective tissue diseases.
The anti-ds-DNA antibody test measures and differentiates these antibody levels in a serum sample, using radioimmunoassay, agglutination, complement fixation, or immunoelectrophoresis. If anti-ds-DNA antibodies are present, they combine with native DNA and form complexes that are too large to pass through a membrane filter. The test counts these oversized complexes.
Procedure And Posttest Care
An anti-ds-DNA antibody level less than 25 IU is considered negative for SLE.
Elevated anti-ds-DNA antibody levels may indicate SLE. Values of 25 to 30 IU are considered borderline positive. Values of 31 to 200 IU are positive, and those greater than 200 IU are strongly positive.
Depressed anti-ds-DNA antibody levels may follow immunosuppressive therapy, demonstrating effective treatment of SLE.
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