Some diabetic patients form antibodies to the insulin they take. These antibodies bind with some of the insulin, making less insulin available for glucose metabolism and necessitating increased insulin dosages. This phenomenon is known as insulin resistance.
Performed on the blood of a diabetic patient receiving insulin, the antiinsulin antibody test detects insulin antibodies. Insulin antibodies are immunoglobulins, called anti-insulin Ab. The most common type of anti-insulin Ab is immunoglobulin G (IgG), but anti-insulin Ab is also found in the other four classes of immunoglobulinsIgA, IgD, IgE, and IgM. IgM may cause insulin resistance, and IgE has been associated with allergic reactions.
Procedure And Posttest Care
There should be less than 3% binding of the patient's serum with labeled beef, human, and pork insulin.
Elevated levels may occur in insulin allergy or resistance and in factitious hypoglycemia.
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